A label meaning a result would be unusual if pure chance were the only thing going on — typically a p-value below 0.05.
Visual intuition
ordinary under model
surprise zone
observed
A small p-value lands far into the surprise zone
'Significant' just means the observed result lands in the surprise zone — too far out to blame comfortably on chance.
Example
In an illustrative trial, 60 of 100 treated patients recover versus 45 of 100 on placebo — a near 0.03, below the usual 0.05 line, so the difference would be called statistically significant.
How It Works
Flip a coin 100 times and get 61 heads: if the coin were fair, a result that lopsided would be rare, so we call it statistically significant. That is all the label certifies — hard to blame on alone. It does not the effect is large, important, or proven: with a huge a trivial 0.2-point difference can be significant, and with a small sample a big real effect can fail the test.