Math Says Yes
Glossary term

False Positive

A test result that says something is there when it is not — a healthy person flagged as positive.

Visual intuition

3 in 100
before new evidence
Every alarm among the 97 is a false positive
Only the 3 highlighted people truly have the condition. Any positive result among the other 97 is a false positive — and because the 97 outnumber the 3, false alarms can easily outnumber real ones as the condition gets rarer.

Formula

false-positive rate = 1 - specificity

Example

With a 99%-sensitive, 99%-specific test and a 1-in-1,000 condition, testing 10,000 people yields about 10 true positives and about 100 false positives — a positive result is real only about 9% of the time.

How It Works

A false positive is an alarm without a fire: the test says positive, the truth says no. Every false positive comes from the group without the condition — and that group is usually the overwhelming majority, so even a small false-alarm rate, multiplied across many healthy people, produces piles of them. Screen 10,000 people for a 1-in-1,000 condition with a 99%-specific test and about 100 healthy people get flagged, against only about 10 true positives: most alarms are false. In hypothesis testing, the same mistake — flagging an effect that is not there — is called a type I error.